A 54-Years-Old Man Known Case of Hypertension, Diabetes Mellitus, Obesity Having Pyogenic Meningitis Due to Streptococcus Agalactiea Complicated by Multiple Small Abscesses Over Meninges, Metabolic Acidosis, Acute Kidney Injury, Transaminitis, DIC And ARD

Main Article Content

Khin Phyu Pyar
Moe Zaw Myint
Khine Lwin
Sa Thiha
Thaw Zin Oo
Nay Myo Lwin
Thidar Sein
Hein Zaw Zaw
Sai Naing
Min Zin
Ye Zarni
Kyaw Wunna
Hein Zaw

Abstract

Case Summary


A 54-years-old man presented with 3 days history of fever and headache followed by acute confusion. He was a known case of hypertension and diabetes mellitus for 10 years. He was obese; neck rigidity was noted; Glasgow Coma Scale was 9/15 (E3,V1, M5). Cerebrospinal fluid examination showed high protein, low normal sugar with cells predominantly neutrophils compatible with pyogenic meningitis; Streptococcus agalactiea was detected in CSF. It was complicated by metabolic acidosis, acute kidney injury, transaminitis, DIC and ARDS. He passed away 58 hours after hospitalization. Autopsy findings were discussed.

Article Details

How to Cite
Pyar, Khin Phyu, Moe Zaw Myint, Khine Lwin, Sa Thiha, Thaw Zin Oo, Nay Myo Lwin, Thidar Sein, Hein Zaw Zaw, Sai Naing, Min Zin, Ye Zarni, Kyaw Wunna, and Hein Zaw. 2025. “A 54-Years-Old Man Known Case of Hypertension, Diabetes Mellitus, Obesity Having Pyogenic Meningitis Due to Streptococcus Agalactiea Complicated by Multiple Small Abscesses Over Meninges, Metabolic Acidosis, Acute Kidney Injury, Transaminitis, DIC And ARD”. International Journal of Medical Science and Clinical Research Studies 5 (09):1494-1509. https://doi.org/10.47191/ijmscrs/v5-i09-01.
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References

I. Abdelradi, A., Murphy, A., & Ahasic, A. M. (2020). Invasive Streptococcus Agalactiae Causing Meningitis, Ventriculitis, and Endocarditis in a Non-Pregnant Adult. Cureus, 12(11), e11412. https://doi.org/10.7759/cureus.11412

II. Al-Bayati, A., Douedi, S., Alsaoudi, G., Mosseri, M., Albustani, S., Upadhyaya, V., Gornish, N., & Elsawaf, M. (2020). Meningitis from invasive Streptococcus agalactiae in a healthy young adult. IDCases, 21, e00907.

https://doi.org/10.1016/j.idcr.2020.e00907

III. Ali, B., Hamdan, A., Horanieh, E., & Shakaroun, N. (2024). Bacterial meningitis associated cerebral vasculitis: A case report and review of the literature. Clinical Infection in Practice, 23, 100366. https://doi.org/10.1016/j.clinpr.2024.100366

IV. Bîrluţiu, V., Luca, C. M., & Bîrluțiu, R.-M. (2018). Streptococcus agalactiae meningoencephalitis associated with gastroesophageal reflux disease and chronic proton pump inhibitors use, in a 9 month-old infant: A case report. BMC Pediatrics, 18(1), 21. https://doi.org/10.1186/s12887-018-0995-0

V. Borriello, G., Fusco, G., Greco, F., Mauro, M. V., Barca, L., Limone, A., Garzi Cosentino, M., Campione, A., Rinaldi, A., Dodaro, S., De Carlo, E., Greco, S., Vangeli, V., Paradiso, R., & Mastroianni, A. (2025). First Report of Streptococcus agalactiae Meningitis in a Non-Pregnant Adult in Italy. Microorganisms, 13(5).

https://doi.org/10.3390/microorganisms13050978

VI. Chen, D., Tang, B., Li, Y., Zheng, K., Li, X., Chen, W., Gao, F., Gao, Y., & Shi, K. (n.d.).

VII. Cho, H. K., Lee, H., Kang, J. H., Kim, K. N., Kim, D. S., Kim, Y. K., Kim, J. S., Kim, J.-H., Kim, C. H., Kim, H. M., Park, S.-E., Oh, S. H., Chung, E. H., Cha, S. H., Choi, Y. Y., Hur, J. K., Hong, Y. J., Lee, H. J., & Kim, K.-H. (2010). The Causative Organisms of Bacterial Meningitis in Korean Children in 1996-2005. J Korean Med Sci, 25(6), 895–899.

VIII. Germano, N., Sibbel, M. G., Summerfield, D., & Pitzenberger, A. (2019). Group B streptococcus meningitis complicated by periodic lateralising epileptiform discharges in an elderly patient with type 2 diabetes mellitus. BMJ Case Reports, 12(8), e228040. https://doi.org/10.1136/bcr-2018-228040

IX. Hasbun, R. (2022). Progress and Challenges in Bacterial Meningitis: A Review. JAMA, 328(21), 2147–2154. https://doi.org/10.1001/jama.2022.20521

X. Hoffman, O., & Weber, R. J. (2009). Pathophysiology and treatment of bacterial meningitis. Therapeutic Advances in Neurological Disorders, 2(6), 1–7

.https://doi.org/10.1177/1756285609337975

XI. Hollasch, H., Niesen, W.-D., & Bardutzky, J. (2019). Meningitis Caused by Streptococcus agalactiae after Professional Tooth Cleaning: First Case. Case Reports in Neurology, 11(1), 1–3. https://doi.org/10.1159/000495747

XII. Hudson, A., Bobo, D., Rueda Prada, L., Dumic, I., Petcu, E., Cardozo, M., & Shweta, F. (2023). Mania: An atypical presentation of probable Streptococcus agalactiae meningoencephalitis. IDCases, 33, e01817. https://doi.org/10.1016/j.idcr.2023.e01817

XIII. Khan, F. Y. (2016). Streptococcus agalactiae Meningitis in Adult Patient: A Case Report and Literature Review. Case Reports in Infectious Diseases, 2016(1), 6183602.

https://doi.org/10.1155/2016/6183602

XIV. Kim, B. J., McDonagh, M. A., Deng, L., Gastfriend, B. D., Schubert-Unkmeir, A., Doran, K. S., & Shusta, E. V. (2019). Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells. Fluids and Barriers of the CNS, 16(1), 26. https://doi.org/10.1186/s12987-019-0146-5

XV. Kuzume, D., Morimoto, Y., Kinboshi, M., Yoshida, T., & Yamasaki, M. (2019). A rare case of Streptococcus agalactiae meningitis in previously healthy adult. Rinsho Shinkeigaku, 59(7), 448–450. https://doi.org/10.5692/clinicalneurol.cn-001287

XVI. Niemelä, S., Lempinen, L., Löyttyniemi, E., Oksi, J., & Jero, J. (2023). Bacterial meningitis in adults: A retrospective study among 148 patients in an 8-year period in a university hospital, Finland. BMC Infectious Diseases, 23(1), 45.

https://doi.org/10.1186/s12879-023-07999-2

XVII. Oyanguren, B., Esteban, L., Guillán, M., de Felipe, A., Alonso Cánovas, A., Navas, E., Quereda, C., & Corral, I. (n.d.). Central nervous system involvement in adult patients with invasive infection caused by Streptococcus agalactiae. Neurología (English Edition).

https://doi.org/10.1016/j.nrleng.2015.02.001

XVIII. Patterson, H., Saralahti, A., Parikka, M., Dramsi, S., Trieu-Cuot, P., Poyart, C., Rounioja, S., & Rämet, M. (2012). Adult zebrafish model of bacterial meningitis in Streptococcus agalactiae infection. Developmental & Comparative Immunology, 38(3), 447–455. https://doi.org/10.1016/j.dci.2012.07.007

XIX. Pomar, V., Benito, N., Duch, P., Colomé, M., Rivera, A., & Domingo, P. (2023). Acute Bacterial Meningitis in Healthy Adult Patients: A Prospective Cohort Study. Journal of Clinical Medicine, 12(11). https://doi.org/10.3390/jcm12113624

XX. Thigpen, M. C., Whitney, C. G., Messonnier, N. E., Zell, E. R., Lynfield, R., Hadler, J. L., Harrison, L. H., Farley, M. M., Reingold, A., Bennett, N. M., Craig, A. S., Schaffner, W., Thomas, A., Lewis, M. M., Scallan, E., & Schuchat, A. (2011). Bacterial meningitis in the United States, 1998-2007. The New England Journal of Medicine, 364(21), 2016–2025. https://doi.org/10.1056/NEJMoa1005384

XXI. Tsalta-Mladenov, M., Dimitrova, V., Georgieva, D., & Andonova, S. (2022). Streptococcus Agalactiae Meningitis Presented with Cerebral Infarction in Adult Patient – Clinical Case and Review. Neurology India, 70, 2145–2148.

https://doi.org/10.4103/0028-3886.359190

XXII. Tsalta-Mladenov, M. E., Dimitrova, V. M., Georgieva, D. K., & Andonova, S. P. (2022). Streptococcus Agalactiae Meningitis Presented with Cerebral Infarction in Adult Patient – Clinical Case and Review. Neurology India, 70(5). https://journals.lww.com/neur/fulltext/2022/70050/streptococcus_agalactiae_meningitis_presented_with.67.aspx

XXIII. Wall, E. C., Chan, J. M., Gil, E., & Heyderman, R. S. (2021). Acute bacterial meningitis. Current Opinion in Neurology, 34(3).

https://journals.lww.com/co-neurology/fulltext/2021/06000/acute_bacterial_meningitis.19.aspx

XXIV. Weyori, E. W., Abubakari, B. B., Nkrumah, B., Abdul-Karim, A., Abiwu, H. A. K., Kuugbee, E. D., Yidana, A., Ziblim, S.-D., Nuertey, B., Weyori, B. A., Yakubu, E. B., Azure, S., Koyiri, V. C., & Adatsi, R. K. (2023). Predictive signs and symptoms of bacterial meningitis isolates in Northern Ghana. Scientific Reports, 13(1), 13400.

https://doi.org/10.1038/s41598-023-38253-z

XXV. Zainel, A., Mitchell, H., & Sadarangani, M. (2021). Bacterial Meningitis in Children: Neurological Complications, Associated Risk Factors, and Prevention. Microorganisms, 9(3). https://doi.org/10.3390/microorganisms9030535

XXVI. Zaky, S., Elbadry, M., Saeed, M. A., Fathelbab, H., Abdelsalam, F., Abdel-Hamid, M. G., Eid, A., Bakr, A., Maher, A., Abdelrahman, M. M., Metwally, M. A., Berengy, M. S., AlMowafy, E. A., Goabar, H., Baki, A. A., Corie, A., Hammad, O., Elsharkawy, E., Saad, A., … Essmat, G. (2025). Management of acute bacterial meningitis in a limited resource setting: An Egyptian consensus model. The Egyptian Journal of Internal Medicine, 37(1), 13. https://doi.org/10.1186/s43162-025-00398-w

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