A 53-Year-Old Man Who Underwent Living Donor Kidney Transplant Had Right Femoral Vein Thrombosis, Right Internal Iliac Artery AtheromatousPlaque, Ischemic Reperfusion Injury, Acute Kidney Injury, Septicemia, Septic Shock Due to Burkholderia Cepacia, Metabolic Acidosis, Adult Respiratory Distress Syndrome, Ischemic Heart Disease and Diabetic Autonomic Neuropathy: Multiplication of Drops!

Main Article Content

Khin Phyu Pyar
Yan Naung
Aung Kyaw Tun
Chann Myei
Soe Win Hlaing
Zar Ni Htet Aung
Thant Zin Oo
Ye Htook Maung
Aung Zaw Htet
Moe Htun Zaw
Kyaw Thu Yein Lwin
Lay Maung Maung
Ye Min Hein
Lynn Htet Aung
Min Aung Hein
Chan Pyae Aung
Myat Kyaw
Myo Min Thant
Myat Ko Ko
Htun Htun Oo
Nyein Chan Ko

Abstract

A 53-year-old man was on maintenance hemodialysis with right permanent catheter for 2 years because of non-functioning arterio-venous fistular (AVF). He had long standing diabetes mellitus with autonomic neuropathy. Right femoral vein and internal iliac vein were found to be thrombosed during living donor kidney transplant. Donor-renal vein was connected to right external iliac vein. Anastomosis of donor’s renal artery to right external iliac artery was done because of atheromatous plaque at right internal iliac artery. Revision of venous anastomosis was done due to venous out flow obstruction noticed during ureter anastomosis. It resulted in longer total ischemic time, 45 minutes, and caused ischemic reperfusion injury. Intraoperative blood pressure varied  95/60 mmHg to 110/70 mmHg with two inotropes. It was complicated by septic shock, metabolic acidosis, adult respiratory distress syndrome (ARDS), and acute kidney injury (AKI). Though antibiotics, triple inotropes, hemodiafiltration and ventilatory support were tried, the patient could not make it. Blood culture obtained 5 days after death revealed Burkholderia cepacia.

Article Details

How to Cite
Phyu Pyar, Khin, Yan Naung, Aung Kyaw Tun, Chann Myei, Soe Win Hlaing, Zar Ni Htet Aung, Thant Zin Oo, Ye Htook Maung, Aung Zaw Htet, Moe Htun Zaw, Kyaw Thu Yein Lwin, Lay Maung Maung, Ye Min Hein, Lynn Htet Aung, Min Aung Hein, Chan Pyae Aung, Myat Kyaw, Myo Min Thant, Myat Ko Ko, Htun Htun Oo, and Nyein Chan Ko. 2026. “A 53-Year-Old Man Who Underwent Living Donor Kidney Transplant Had Right Femoral Vein Thrombosis, Right Internal Iliac Artery AtheromatousPlaque, Ischemic Reperfusion Injury, Acute Kidney Injury, Septicemia, Septic Shock Due to Burkholderia Cepacia, Metabolic Acidosis, Adult Respiratory Distress Syndrome, Ischemic Heart Disease and Diabetic Autonomic Neuropathy: Multiplication of Drops!”. International Journal of Medical Science and Clinical Research Studies 6 (05):951-62. https://doi.org/10.47191/ijmscrs/v6-i5-23.
Section
Articles

References

I. Adelmann, D., & Legrand, M. (2024). Intraoperative blood pressure management during kidney transplantation: Grafts under pressure. American Journal of Transplantation, 24(11), 1925–1927. https://doi.org/10.1016/j.ajt.2024.06.017

II. Barros, V., Rocha, V., Garcia, V., & Garcia, C. (2003). Anaphylactic shock after retreatment with Basiliximab. Transplantation Proceedings, 35, 579. https://doi.org/10.1016/S0041-1345(02)03406-1

III. Benjamens, S., van den Berg, T. A. J., Kuipers, T. G. J., Moers, C., Berger, S. P., Leuvenink, H. G. D., & Pol, R. A. (2020). Kidney temperature during living donor kidney transplantation is associated with short-term measured glomerular filtration rate – a prospective study. Transplant International, 33(2), 174–180. https://doi.org/10.1111/tri.13528

IV. Bushueva, A., Korneeva, D., & Strongin, L. (2025). The influence of cardiovascular autonomic neuropathy on blood pressure profile in patients with a combination of diabetes mellitus type 2 and arterial hypertension. FOCUS. Endocrinology, 6, 6–11. https://doi.org/10.62751/2713-0177-2025-6-4-01

V. Chatauret, N., Badet, L., Barrou, B., & Hauet, T. (2014). Ischemia-reperfusion: From cell biology to acute kidney injury. Progrès En Urologie, 24, S4–S12. https://doi.org/https://doi.org/10.1016/S1166-7087(14)70057-0

VI. Dube, P., DeRiso, A., Patel, M., Battepati, D., Khatib-Shahidi, B., Sharma, H., Gupta, R., Malhotra, D., Dworkin, L., Haller, S., & Kennedy, D. (2021). Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall. Biomedicines, 9(4). https://doi.org/10.3390/biomedicines9040404

VII. Fırat, N., Karacan, A., Akın, E., Altıntoprak, F., Çelebi, F., Salihi, S., Kocatürk, E. M., Küçük, İ. F., & Dheir, H. (2025). Comparison of Double Renal Artery Anastomosis With Single Renal Artery Anastomosis in Kidney Transplant Recipients; Is There Any Effect on Graft Function? Transplantation Proceedings, 57(9), 1744–1747. https://doi.org/10.1016/j.transproceed.2025.07.003

VIII. Fuquay, R., Renner, B., Kulik, L., McCullough, J. W., Amura, C., Strassheim, D., Pelanda, R., Torres, R., & Thurman, J. M. (2013). Renal ischemia-reperfusion injury amplifies the humoral immune response. Journal of the American Society of Nephrology : JASN, 24(7), 1063–1072. https://doi.org/10.1681/ASN.2012060560

IX. Gangaram, U., Ramya, T., Jithendra, K., & Mohan, D. R. (2020). Burkholderia cepacia an emerging cause of septicaemia, in an intensive care unit from a tertiary care hospital, Nellore, India. International Journal of Advances in Medicine, 7(3), 413–417. https://doi.org/10.18203/2349-3933.ijam20200591

X. Gogan, A., Potre, O., Avram, V.-F., Andor, M., Caruntu, F., & Timar, B. (2025a). Cardiac Autonomic Neuropathy in Diabetes Mellitus: Pathogenesis, Epidemiology, Diagnosis and Clinical Implications: A Narrative Review. Journal of Clinical Medicine, 14(3), 671. https://doi.org/10.3390/jcm14030671

XI. Gogan, A., Potre, O., Avram, V.-F., Andor, M., Caruntu, F., & Timar, B. (2025b). Cardiac Autonomic Neuropathy in Diabetes Mellitus: Pathogenesis, Epidemiology, Diagnosis and Clinical Implications: A Narrative Review. Journal of Clinical Medicine, 14(3), 671. https://doi.org/10.3390/jcm14030671

XII. Goyal, V. K., Shekhrajka, P., & Mittal, S. (2025). Perioperative considerations in kidney transplantation: An anaesthesiologist’s perspective. World Journal of Transplantation, 15(4), 107662. https://doi.org/10.5500/wjt.v15.i4.107662

XIII. Gulec, B. (2011). Ischemia Reperfusion Injury in Kidney Transplantation. In D. (Md) M. Trzcinska (Ed.), Kidney Transplantation—New Perspectives. IntechOpen. https://doi.org/10.5772/18289

XIV. Haas, M., Kraus, E. S., Samaniego-Picota, M., Racusen, L. C., Ni, W., & Eustace, J. A. (2002). Acute renal allograft rejection with intimal arteritis: Histologic predictors of response to therapy and graft survival. Kidney International, 61(4), 1516–1526.

https://doi.org/10.1046/j.1523-1755.2002.00254.x

XV. Hernawan Rahmat Muharia, B., Situmorang, G. R., Rasyid, N., Rodjani, A., & Birowo, P. (2025). Comparing anastomosis techniques on ischemia time in multi-arterial kidney grafts: A systematic review and meta-analysis. Medical Journal of Indonesia, 34(1), 30–36. https://doi.org/10.13181/mji.oa.257527

XVI. Ho, A., Zaltzman, J., Hare, G. M. T., Chen, L., Fu, L., Tarlo, S. M., & Vadas, P. (2019). Severe and near-fatal anaphylactic reactions triggered by chlorhexidine-coated catheters in patients undergoing renal allograft surgery: A case series. Canadian Journal of Anesthesia/Journal Canadien d’anesthésie, 66(12), 1483–1488.

https://doi.org/10.1007/s12630-019-01441-5

XVII. Hofer, G., Goode, S., Renström, F., Brändle, M., & Cavelti-Weder, C. (2026). Diabetes mellitus complications and their association with patient-reported outcome measures: A longitudinal study of the SwissDiab cohort. Diabetes Research and Clinical Practice, 236, 113263.

https://doi.org/10.1016/j.diabres.2026.113263

XVIII. Huang, A. J., Sharma, G. K., Parikh, R., Jin, Z., Darras, F. S., & Bergese, S. D. (2025). Molecular Mechanisms and Potential Therapeutic Targets of Ischemia–Reperfusion Injury in Kidney Transplantation. Current Issues in Molecular Biology, 47(4).

https://doi.org/10.3390/cimb47040282

XIX. Ji, J., Ma, Y., Liu, X., Zhou, Q., Zheng, X., Chen, Y., Li, Z., & Yang, L. (2024). Identification of Renal Ischemia-Reperfusion Injury Subtypes and Predictive Model for Graft Loss after Kidney Transplantation Based on Programmed Cell Death-Related Genes. Kidney Diseases, 10(6), 450–467. https://doi.org/10.1159/000540158

XX. Khan, T. F. T., Ahmad, N., Serageldeen, A. S., & Fourtounas, K. (2019). Implantation Warm Ischemia Time in Kidney Transplant Recipients: Defining Its Limits and Impact on Early Graft Function. Annals of Transplantation, 24, 432–438. https://doi.org/10.12659/AOT.916012

XXI. Kukla, U., Cholewa, H., Chronowska, J., Goc, T., Lieber, E., Kolonko, A., Budziński, G., Ziaja, J., Więcek, A., & Cierpka, L. (2016a). Effect of the Second Warm Ischemia Time and Its Components on Early and Long-term Kidney Graft Function. Transplantation Proceedings, 48, 1365–1369. https://doi.org/10.1016/j.transproceed.2015.11.042

XXII. Kukla, U., Cholewa, H., Chronowska, J., Goc, T., Lieber, E., Kolonko, A., Budziński, G., Ziaja, J., Więcek, A., & Cierpka, L. (2016b). Effect of the Second Warm Ischemia Time and Its Components on Early and Long-term Kidney Graft Function. Transplantation Proceedings, 48, 1365–1369. https://doi.org/10.1016/j.transproceed.2015.11.042

XXIII. Lee, S.-Y., Lee, Y.-S., Choi, H.-M., Ko, Y.-S., Lee, H.-Y., Jo, S.-K., Cho, W.-Y., & Kim, H.-K. (2012). Distinct pathophysiologic mechanisms of septic acute kidney injury: Role of immune suppression and renal tubular cell apoptosis in murine model of septic acute kidney injury. In Critical Care Medicine (Vol. 40, Issue 11, pp. 2997–3006). https://journals.lww.com/ccmjournal/fulltext/2012/11000/distinct_pathophysiologic_mechanisms_of_septic.10.aspx

XXIV. Lian, Y., Li, P., Guo, Y., Tao, Y., Liu, Y., Liang, Z., & Zhu, S. (2024). Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects. Frontiers in Immunology, Volume 15-2024. https://doi.org/10.3389/fimmu.2024.1495394

XXV. Liao, C.-H., Chang, H.-T., Lai, C.-C., Huang, Y.-T., Hsu, M.-S., Liu, C.-Y., Yang, C.-J., & Hsueh, P.-R. (2011). Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. Diagnostic Microbiology and Infectious Disease, 70(2), 260–266. https://doi.org/10.1016/j.diagmicrobio.2011.01.008

XXVI. Lushina, N., Lee, A., Cuadra, S., Whang, M., & Sun, H. (2019). External Iliac Artery Dissection During Renal Transplantation: A Case Report and Literature Review. Transplantation Proceedings, 51(2), 538–

https://doi.org/10.1016/j.transproceed.2018.12.021

XXVII. Lusito, Nurani, A., Partiningrum, D. L., Arwanto, A., Lestariningsih, & Chasani, S. (2021). RELATIONSHIP BETWEEN WARM ISCHEMIC TIME AND RESISTIVE INDEX ON CREATININ REDUCTION RATIO DAY TWO AFTER LIVING KIDNEY DONOR TRANSPLANTATION. Journal of Midwifery and Health Science of Sultan Agung, 1(1), 1–13. https://doi.org/10.30659/jmhsa.v1i1.4

XXVIII. Mahajan, N., Heer, M. K., & Trevillian, P. R. (n.d.).

XXIX. Mahajan, N., Heer, M. K., & Trevillian, P. R. (2023). Renal transplant anastomotic time–Every minute counts! Frontiers in Medicine, Volume 9-2022. https://doi.org/10.3389/fmed.2022.1024137

XXX. Marzouk, K., Lawen, J., Alwayn, I., & Kiberd, B. A. (2013). The impact of vascular anastomosis time on early kidney transplant outcomes. Transplantation Research, 2(1), 8. https://doi.org/10.1186/2047-1440-2-8

XXXI. Mayhew, M., Solomon, R., LaGuardia, H., Shaw, K., Arenas, J., & Hranjec, T. (2022). Vascular Complications in Renal Transplantation: Surgical Salvage of Renal Artery Dissection. Transplantation Direct, 8(6), e1340. https://doi.org/10.1097/TXD.0000000000001340

XXXII. McHenry, M. C., Braun, W. E., Popowniak, K. L., Banowsky, L. H., & Deodhar, S. D. (1976). Septicemia in Renal Transplant Recipients. Urologic Clinics of North America, 3(3), 647–666. https://doi.org/https://doi.org/10.1016/S0094-0143(21)01139-3

XXXIII. Montaigne, D., Alhawajri, N., Jacquelinet, M., Coppin, A., Frimat, M., Bouyé, S., Lebuffe, G., Staels, B., Jacquelinet, C., & Hazzan, M. (2021). Day-Time Declamping Is Associated with Better Outcomes in Kidney Transplantation: The Circarein Study. Journal of Clinical Medicine, 10, 2322. https://doi.org/10.3390/jcm10112322

XXXIV. Nieuwenhuijs-Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J. S. F., Pol, R. A., Struys, M. M. R. F., Ploeg, R. J., & Leuvenink, H. G. D. (2020a). Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. Journal of Clinical Medicine, 9(1). https://doi.org/10.3390/jcm9010253

XXXV. Nieuwenhuijs-Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J. S. F., Pol, R. A., Struys, M. M. R. F., Ploeg, R. J., & Leuvenink, H. G. D. (2020b). Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. Journal of Clinical Medicine, 9(1). https://doi.org/10.3390/jcm9010253

XXXVI. Nugroho, E. A., Hidayat, A., & Hidayat, A. T. (2019). Correlation of Warm and Cold Ischemic Time to Graft Function in Kidney Transplant: A Single Centre Report. The Open Urology and Nephrology Journal, 12, 66–71. https://doi.org/10.2174/1874303X01912010066

XXXVII. Pongpruksa, C., Khampitak, N., Bunnapradist, S., & Xia, V. W. (2026). Intraoperative Mean Arterial Pressure in Relation to Delayed Graft Function in Living-Donor Kidney Transplantation. Transplantation Proceedings, 58(1), 45–51. https://doi.org/10.1016/j.transproceed.2025.12.014

XXXVIII. Ponticelli, C., Reggiani, F., & Moroni, G. (2022). Delayed Graft Function in Kidney Transplant: Risk Factors, Consequences and Prevention Strategies. Journal of Personalized Medicine, 12(10). https://doi.org/10.3390/jpm12101557

XXXIX. Pop-Busui, R. (2010). Cardiac autonomic neuropathy in diabetes: A clinical perspective. Diabetes Care, 33(2), 434–441. https://doi.org/10.2337/dc09-1294

XL. Punia, S., Sadasukhi, N., Sadasukhi, T. C., Gupta, H. L., Gupta, M., & Sharma, A. (2023). To Compare the Effect of Warm Ischemia Time and its Significance, if any—Open versus Laparoscopic Donor Nephrectomy. Indian Journal of Transplantation, 17(4). https://journals.lww.com/ijjt/fulltext/2023/17040/to_compare_the_effect_of_warm_ischemia_time_and.9.aspx

XLI. Pyar, K. P., Myint, A. K., Myint, M. Z., Shwe, W. K., Aung, Z. N. H., Maung, Y. H., Hlaing, S. W., Aung, S. M., LinMaung, N., Latt, C. N., Thant, M. M., Kyaw, S., Mya, T. M., Aung, W. L., Win, T. A., & Hlaing, O. (2025). Abdominal Aortic Calcification and Its Determinants in People Living with Maintenance Haemodialysis in 2 Selected Public Hospitals from Myanmar. International Journal of Medical Science and Clinical Research Studies, 5(11), 1797–1813. https://doi.org/10.47191/ijmscrs/v5-i11-01

XLII. Roth, N., Kalteis, M., Krause, A., Rösch, C., Huber, J., Enkner, W., Haller, M., Cejka, D., Függer, R., & Biebl, M. (2024). Vascular reconstructions in living donor kidney transplantation: A single-center experience over the last 17 years. Frontiers in Transplantation, 3, 1488277. https://doi.org/10.3389/frtra.2024.1488277

XLIII. Salvadori, M., Rosso, G., & Bertoni, E. (2015). Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World Journal of Transplantation, 5(2), 52–67. https://doi.org/10.5500/wjt.v5.i2.52

XLIV. Sasaki, H., Chikaraishi, T., Furuhata, S., Tsutsumi, H., Miyano, S., Nakano, T., Sato, Y., Kimura, K., & Takahashi, T. (2007). Anaphylactic reaction after initial exposure of Basiliximab: Case reports. Transplantation Proceedings, 39(10), 3457–3459. https://doi.org/10.1016/j.transproceed.2007.08.104

XLV. Sauenram, N., Sillabutra, J., Viwatwongkasem, C., & Satitvipawee, P. (2023). Estimation of the onset time of diabetic complications in type 2 diabetes patients in Thailand: A survival analysis. PHRP, 14(6), 508–519. https://doi.org/10.24171/j.phrp.2023.0084

XLVI. Savransky, V., Molls, R. R., Burne-Taney, M., Chien, C.-C., Racusen, L., & Rabb, H. (2006). Role of the T-cell receptor in kidney ischemia–reperfusion injury. Kidney International, 69(2), 233–238. https://doi.org/https://doi.org/10.1038/sj.ki.5000038

XLVII. Serhiyenko, V., Serhiyenko, A., Hotsko, M., Markevich, Y., Markevich, M.-Y., Segin, V., & Serhiyenko, L. (2023). Diabetic Cardiac Autonomic Neuropathy: Link between Heart Rate Variability, Violated Blood Pressure Pattern, and Pulse Wave Velocity. In M. E. Hernández Aguilar & G. E. Aranda Abreu (Eds.), Topics in Autonomic Nervous System. IntechOpen.

https://doi.org/10.5772/intechopen.112894

XLVIII. Shrestha, K. K., Shrestha, P. C., Pradhananga, S., & Lama, S. (2023). Mean Warm Ischemia Time among Kidney Transplant Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA; Journal of the Nepal Medical Association, 61(262), 519–521.

https://doi.org/10.31729/jnma.8190

XLIX. Steenvoorden, T. S., van Duin, R. E., Rood, J. A. J., Peters-Sengers, H., Nurmohamed, A. S., Bemelman, F. J., Vogt, L., & van der Heijden, J. W. (2023). Alkaline phosphatase to treat ischaemia–reperfusion injury in living-donor kidney transplantation: APhIRI I feasibility pilot study. British Journal of Clinical Pharmacology, 89(12), 3629–3636.

https://doi.org/10.1111/bcp.15871

L. Tennankore, K. K., Kim, S. J., Alwayn, I. P. J., & Kiberd, B. A. (2016). Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation. Kidney International, 89(3), 648–658.

https://doi.org/10.1016/j.kint.2015.09.002

LI. Toufeeq Khan, T. F., Ahmad, N., Serageldeen, A. S., & Fourtounas, K. (2019a). Implantation Warm Ischemia Time in Kidney Transplant Recipients: Defining Its Limits and Impact on Early Graft Function. Annals of Transplantation, 24, 432–438.

LII. Toufeeq Khan, T. F., Ahmad, N., Serageldeen, A. S., & Fourtounas, K. (2019b). Implantation Warm Ischemia Time in Kidney Transplant Recipients: Defining Its Limits and Impact on Early Graft Function. Annals of Transplantation, 24, 432–438.

LIII. van Laer, F., Raes, D., Vandamme, P., Lammens, C., Sion, J. P., Vrints, C., Snoeck, J., & Goossens, H. (1998). An Outbreak of Burkholderia cepacia With Septicemia on a Cardiology Ward. Infection Control & Hospital Epidemiology, 19(2), 112–113.

https://doi.org/10.1086/647778

LIV. Varzideh, F., Jankauskas, S. S., Mone, P., Kansakar, U., & Santulli, G. (2025). Autonomic neurotransmission in cardiovascular regulation and pathophysiology. Frontiers in Neuroscience, 19,

https://doi.org/10.3389/fnins.2025.1739330

LV. Vascular Calcification Work Group, Goodman, W. G., London, G., Amann, K., Block, G. A., Giachelli, C., Hruska, K. A., Ketteler, M., Levin, A., Massy, Z., McCarron, D. A., Raggi, P., Shanahan, C. M., & Yorioka, N. (2004). Vascular calcification in chronic kidney disease. American Journal of Kidney Diseases, 43(3), 572–579.

https://doi.org/10.1053/j.ajkd.2003.12.005

LVI. Ville, S., Lorent, M., Kerleau, C., Asberg, A., Legendre, C., Morelon, E., Buron, F., Garrigue, V., Le Quintrec, M., Girerd, S., Ladrière, M., Albano, L., Sicard, A., Glotz, D., Lefaucheur, C., Branchereau, J., Jacobi, D., & Giral, M. (2021). Timing of Kidney Clamping and Deceased Donor Kidney Transplant Outcomes. Clinical Journal of the American Society of Nephrology : CJASN, 16(11), 1704–1714.

https://doi.org/10.2215/CJN.03290321

LVII. Wang, S., Randall, D. C., Knapp, C. F., Patwardhan, A. R., Nelson, K. R., Karounos, D. G., & Evans, J. M. (2012). Blood pressure regulation in diabetic patients with and without peripheral neuropathy. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 302(5), R541-550. https://doi.org/10.1152/ajpregu.00174.2011

LVIII. Zhao, H., Alam, A., Soo, A. P., George, A. J. T., & Ma, D. (2018). Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond. EBioMedicine, 28, 31–42. https://doi.org/10.1016/j.ebiom.2018.01.025

Most read articles by the same author(s)