Complex Anorectal Fistulas: A Critical Review of Evolving Surgical Techniques, Continence Preservation, And Recurrence Dynamics
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Abstract
Complex anorectal fistulas remains a formidable challenge, And choosing the best surgical approach that will drastically improve the patient's condition and reduce the risk of incontinence remains unclear, requiring a delicate balance between eradicating the infected tract and preserving fecal continence. This critical review assesses the current sphincter-sparing surgical instruments and the method's theoretical origins, success rates and complications. This review includes all available clinical studies, meta-analyses, and guidelines regarding LIFT, TROPIS, ERAF, FiLaC, VAAFT, and biologic therapy. The traditional sphincter-sparing methods differ. For LIFT they are proven successful for 60%-76%, but because the lateral tract is recovered it is considered that the TROPIS is a better procedure (primary healing rate of 85%-94%) which focuses on ISTAC and DRAPED. The least invasive thermal and endoscopic therapies ensure continuation but show higher recurrence rates (20%-43%). When intersphincteric sepsis is treated and external anal sphincter is kept out of the picture, the most durable results are available. The TROPIS is a paradigm change, from modern management perspective.
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References
I. Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg.
;63(1):1-12. https://doi.org/10.1002/bjs.1800630102
II. Garg P. Intersphincteric tract is like an abscess in a closed space: The ISTAC principle. World J Gastroenterol.2017;23(47):8434–8435. https://doi.org/10.3748/wjg.v23.i47.8434
III. Gaertner WB, Burgess PL, Davids JS, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Anorectal Abscess, Fistula-in-Ano, and
Rectovaginal Fistula. Dis Colon Rectum.
;65(8):964-985 (https://doi.org/10.1097/DCR.0000000000002473)
IV. Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K. Total sphincter-saving alteration of fistula tract (LIFT) procedure for fistula-in-ano. J Med Assoc Thai. 2007;90(3):581-586.
V. Hong KD, Kang S, Kalaskar S, Wexner SD. Ligation of intersphincteric fistula tract (LIFT) to treat anal fistula: systematic review and meta-analysis. Tech Coloproctol. 2014;18(8):685-691. https://doi.org/10.1007/s10151-014-1183-3
VI. Garg P. Transanal opening of intersphincteric space (TROPIS) - A new procedure for difficult horseshoe-like anal fistulas. Int J Surg. 2017;40:130-134. https://doi.org/10.1016/j.ijsu.2017.11.026
VII. Wang C, Huang T, Wang X. Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: a meta‑analysis. Exp Ther Med. 2024;28:306. https://doi.org/10.3892/etm.2024.12595
VIII. Wilhelm A. A new technique for sphincter-preserving anal fistula repair using a novel radial emitting laser probe. Tech Coloproctol. 2011;15(4):445-449. https://doi.org/10.1007/s10151-011-0726-0
IX. Meinero P, Mori L. Video-assisted anal fistula treatment (VAAFT): a novel sphincter-saving procedure for treating complex anal fistulas. Tech Coloproctol.2011;15(4):417-422. https://doi.org/10.1007/s10151-011-0769-2
X. Elfeki H, Shalaby M, Emile SH, et al. A systematic review and meta-analysis of the safety and efficacy of fistula laser closure. Tech Coloproctol. 2020;24(4):265-274. https://doi.org/10.1007/s10151-020-02162-z
XI. Soltani A, Kaiser AM. Endorectal advancement flap for cryptoglandular or Crohn's fistula-in-ano. Dis Colon Rectum. 2010;53(4):486-495.(https://doi.org/10.1007/DCR.0b013e3181ce8b01)
XII. Jayne DG, Scholefield J, Tolan D, et al. A multicenter randomized controlled trial comparing safety, efficacy, and cost-effectiveness of the surgisis anal fistula plug versus surgeon's preference for transsphincteric fistula-in-ano: the FIAT trial. Ann Surg. 2021;273(3):433-441.(https://doi.org/10.1097/SLA.0000000000003981)
XIII. An Y, Gao J, Xu J, et al. Efficacy and safety of 13 surgical techniques for the treatment of complex anal fistula, non-Crohn CAF: a systematic review and network meta-analysis. Int J Surg.
;110(1):441452.(https://doi.org/10.1097/JS9.0000000000000776)
XIV. XIV. Emile SH, Khan SM, Adejumo A, Koroye O. Ligation of intersphincteric fistula tract (LIFT) in treatment of anal fistula: an updated systematic review, meta-analysis, and meta-regression of the predictors of failure. Surgery. 2020;167(2):484-492.https://doi.org/10.1016/j.surg.2019.09.012