Usefulness of the Alvarado Scale in Patients with Suspected Acute Appendicitis in Relation to Imaging Results
Main Article Content
Abstract
Background: Multiple studies demonstrate that the Alvarado Score is less effective than other studies in predicting the incidence of patients with suspected acute appendicitis. It does not distinguish between ages and does not suggest a clinical stage of the disease. However, its use is still current in our unit and in most hospitals in our country.
General Objective: To identify the utility of the Alvarado Score in patients with suspected acute appendicitis in relation to imaging results.
Materials and Methods: Descriptive, observational, cross-sectional, retrospective study, which was carried out with 62 records of patients with suspected acute appendicitis and who were requested imaging studies at the Regional General Hospital 1 of Orizaba, Veracruz with the suspected diagnosis of Acute Appendicitis during the period from December 1, 2017 to November 30, 2022. Patients of any age group and both sexes who came to the emergency service with pain in the right iliac fossa and classified with the Alvarado scale that met the selection criteria were included. This study was conducted from March 1 to September 30, 2023. Data analysis included descriptive statistics for qualitative variables using frequencies and percentages, as well as measures of dispersion. For quantitative variables, such as mean and standard deviation, the Fisher exact test was used between variables with two categories based on the nature of the categorical variables. SPSS 23 and GraphPad Prism 8 software were used.
Resources and infrastructure: those of the institution, the patients, and the researcher.
Group experience: There is a master's degree in science and a radiologist with experience in ultrasound and CT interpretation. A resident physician who will carry out the activities of the research project.
Results: The female sex predominated with a frequency of 40 patients (56.33%) with a mean age of 28.80 years, standard deviation +/- 19.36 (95% CI 22.61-34.99), of the male sex a frequency of 31 patients (43.66%) was observed with a mean age of 28.16 years, standard deviation +/- 17.69, the time of onset of symptoms: 35 patients (49.3%) began with symptoms at 24 hours, followed by 15 patients (21.1%) at 12 hours, 11 patients (15.5%) at 72 hours, 7 patients reported onset of symptoms at 48 hours (9.9%). The relationship between the Alvarado scale and imaging studies was identified using Fisher's exact test. The P value was 0.8791, which is considered statistically insignificant.
Conclusion: The Alvarado score has proven to be a useful, simple, noninvasive, and rapid tool for guiding the diagnosis of acute appendicitis. However, due to its low specificity, the use of imaging studies is always recommended to confirm suspected diagnoses.
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
References
I. Teng TZJ , Thong XR , Lau KY, Balasubramaniam S, Shelat VG. Acute appendicitis-advances and controversies. World J Gastrointest Surg. 2021 ;13 (11):1293–314. DOI : 10.4240/ wjgs.v13.i11.1293
II. Jonas L, Bombil I, Mannell A, University of Witwatersrand, Johannesburg. Unusual histopathologies of the appendix. Wits Journal of Clinical Medicine. 2020 ;2 (2):113.DOI : 10.18772/ 26180197.2020.v2n2a11
III. Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 ;15 (1):27.
DOI : 10.1186/ s13017 -020-00306-3
IV. Withers A , Loveland J. Demographics of pediatric patients presenting with acute appendicitis: A 5-year retrospective review of hospitals served by the Department of Pediatric Surgery at the University of the Witwatersrand. S Afr J Child Health 2019 ;13 (2):69-72.DOI : 10.7196/ SAJCH.2019.v13i2.1557
V. de Jonge J, Scheijmans JCG , van Rossem CC, van Geloven AAW , Boermeester MA, Bemelman WA, et al. Normal inflammatory markers and acute appendicitis: a national multicentre prospective cohort analysis. Int J Colorectal Dis. 2021 ;36 (7):1507–13.DOI : 10.1007/ s00384 -021-03933-7
VI. Shommu NS, Jenne CN, Blackwood J, Joffe AR, Martin DA, Thompson GC, et al. Metabolomic and inflammatory mediator based biomarker profiling as a potential novel method to aid pediatric appendicitis identification. PLoS One. 2018;13(3)DOI : 10.1371/ journal.pone.0193563
VII. Korkut M, Bedel C, Karancı Y, Avcı A, Duyan M. Accuracy of Alvarado, Eskelinen , Ohmann , RIPASA and Tzanakis scores in diagnosis of acute appendicitis; A cross-sectional study. Arch Acad Emerg Med. 2020 ;8 (1): e20 . PMID : 32259117; PMCID : PMC7130437 .
VIII. Altali Alhames K, Martín-Sánchez FJ , Ruiz -Artacho P, Ayuso FJ , Trenchs V, Martínez Ortiz de Zarate M, et al. Diagnostic accuracy of combining C-Reactive protein and Alvarado Score among 2-to-20-year-old patients with acute appendicitis suspected presenting to Emergency Departments. Rev Esp Quimioter . 2021 ;34 (3):220–7.DOI : 10.37201/ req /008.2021
IX. Feng W, Zhao XF, Li MM, Cui HL. A clinical prediction model for complicated appendicitis in children younger than five years of age. BMC Pediatrics. 2020 ;20 (1):401.DOI : 10.1186/ s12887 -020-02286-4.
X. Al- Tarakji , M. et al. (2022) “The role of Alvarado score in predicting acute appendicitis and its severity in correlation to histopathology: A retrospective study in a Qatar population,” Cureus , 14(7), p. e26902 .DOI : 10.7759/ cureus.26902 .
XI. Cotton DM, Vinson DR , Vazquez-Benitez G, Margaret Warton E, Reed ME, Chettipally UK, et al. Validation of the pediatric Appendicitis Risk Calculator (pARC) in a community emergency department setting. Ann Emerg Med. 2019 ;74 (4):471–80.DOI:10.1016 / j.annemergmed.2019.04.023 .
XII. Kharbanda AB, Vazquez-Benitez G, Ballard DW , et al. Development and Validation of a Novel Pediatric Appendicitis Risk Calculator (pARC). Pediatrics. 2018 ;141 (4).DOI : 10.1542/ peds.2017 -2699
XIII. Kharbanda AB, Vazquez-Benitez G, Ballard DW , Vinson DR , Chettipally UK, Dehmer SP, et al. Effect of clinical decision support on diagnostic imaging for pediatric appendicitis: A cluster randomized trial. JAMA Network Open. 2021 ;4 (2).DOI:10.1001 / jamanetworkopen.2020.36344
XIV. Iamwat J, Teerasamit W, Apisarnthanarak P, Noppakunsomboon N, Kaewlai R. Predictive ability of CT findings in the differentiation of complicated and uncomplicated appendicitis: a retrospective investigation of 201 patients undergoing appendectomy at initial admission. Insights Imaging. 2021 ;12 (1):143.DOI : 10.1186/ s13244 -021-01086-3
XV. Awayshih MMA , Nofal MN, Yousef AJ. Evaluation of Alvarado score in diagnosing acute appendicitis. Pan Afr Med J. 2019 ;34:15 .DOI : 10.11604/ pamj.2019.34.15.17803
XVI. Podda M, Pisanu A, Sartelli M, Coccolini F, Damaskos D, Augustin G, et al. Diagnosis of acute appendicitis based on clinical scores: is it a myth or reality? Biomed Act . 2021 ;92 (4).DOI : 10.23750/ abm.v92i4.11666
XVII. Bhangu A, RIFT Study Group on behalf of the West Midlands Research Collaborative. Evaluation of appendicitis risk prediction models in adults with suspected appendicitis: Identifying adults at low risk of appendicitis. Br J Surg. 2020 ;107 (1):73–86.DOI : 10.1002/ bjs.11440
XVIII. Bom WJ , Bolmers MD, Gans SL, van Rossem CC, van Geloven AAW , Bossuyt PMM , et al. Discriminating complicated from uncomplicated appendicitis by ultrasound imaging, computed tomography or magnetic resonance imaging: Systematic review and meta-analysis of diagnostic accuracy. BJS Open. 2021 ;5 (2).DOI : 10.1093/ bjsopen / zraa030
XIX. Vaziri M, Nafissi N, Jahangiri F, Nasiri M. Comparison of the appendicitis inflammatory response and Alvarado scoring systems in the diagnosis of acute appendicitis in children. J Med Life. 2021 ;14 (1):75–80.DOI : 10.25122/ jml -2020-0031
XX. Löfvenberg F, Salö M. Ultrasound for appendicitis: Performance and integration with clinical parameters. Biomed Res Int. 2016;8(2016) http://dx.doi.org/10.1155/2016/5697692
XXI. Rawolle T, Reismann M, Minderjahn MI, Bassir C, Hauptmann K, Rothe K, et al. Sonographic differentiation of complicated from uncomplicated appendicitis. Br J Radiol . 2019 ;92 (1099).DOI : 10.1259/ bjr.20190102
XXII. Neal JT, Monuteaux MC, Rangel SJ , Bachur RG, Barnewolt CE. Does age affect the test performance of secondary sonographic findings for pediatric appendicitis? Pediatrician Radiol . 2021 ;51 (11):2018–26.DOI : 10.1007/ s00247 -021-05100-0
XXIII. Kim I, Kwon H, Choi YJ , Kwak YH , Lee JH, Suh D, et al. Computed tomography scan usage when US results are non-diagnostic for suspected Acute appendicitis in children. Medicine (Baltimore). 2020 ;99 (36).DOI : 10.1097/ MD.0000000000021961
XXIV. Simianu VV , Shamitoff A, Hippe DS, Godwin BD, Shriki JE, Drake FT, et al. The reliability of a standardized reporting system for the diagnosis of appendicitis. Curr Problem Diagn Radiol . 2017 ;46 (4):267–74.DOI:10.1067 / j.cpradiol.2016.07.006 .
XXV. Kim MS, Kwon HJ, Kang KA, Do IG, Park HJ, Kim EY , et al. Diagnostic performance and useful findings of ultrasound re-evaluation for patients with equivocal CT features of acute appendicitis. Br J Radiol . 2018 ;91 (1082).
DOI : 10.1259/ bjr.20170529
XXVI. Rud B, Vejborg TS , Rappeport ED, Reitsma JB , Wille-Jørgensen P. Computed tomography for diagnosis of acute appendicitis in adults. Cochrane Book . 2019 ;2019 (11).DOI : 10.1002/ 14651858.CD009977.pub2 .
XXVII. Lin HA, Tsai HW, Chao CC, Lin SF. Periappendiceal fat-stranding models for discriminating between complicated and uncomplicated acute appendicitis: a diagnostic and validation study. World J Emerg Surg. 2021 ;16 (1):52.DOI : 10.1186/ s13017 -021-00398-5
XXVIII. Sammalkorpi HE, Leppäniemi A, Lantto E, Mentula P. Performance of imaging studies in patients with suspected appendicitis after stratification with adult appendicitis score. World J Emerg Surg. 2017 ;12:6 .DOI : 10.1186/ s13017 -017-0119-4
XXIX. Chawla LS, Toma I, Davison D, Vaziri K, Lee J, Lucas R, et al. Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes. BMC Med Genomics. 2016 ;9 (1).DOI : 10.1186/ s12920-016-0200 -y
XXX. Michelson KA, Reeves SD, Grubenhoff JA, Cruz AT, Chaudhari PP, Dart AH, et al. Clinical features and preventability of delayed diagnosis of pediatric appendicitis. JAMA Network Open. 2021 ;4 (8).DOI : 10.1001/ jamanetworkopen.2021.22248